How aspirin inhibts Cox Enzyme

Aspirin (Acetylsalicylic acid) is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation. Its primary mechanism of action involves the irreversible inhibition of the enzyme Cyclooxygenase-1 (COX-1). Aspirin works by donating an acetyl group to a specific serine residue (Serine 530) located within the hydrophobic channel of the enzyme. This chemical modification physically blocks the channel, preventing the substrate (Arachidonic Acid) from reaching the active